{"id":8037,"date":"2023-08-04T11:54:42","date_gmt":"2023-08-04T04:54:42","guid":{"rendered":"https:\/\/www.talingchanpet.net\/?p=8037"},"modified":"2023-09-13T14:41:22","modified_gmt":"2023-09-13T07:41:22","slug":"%e0%b9%81%e0%b8%99%e0%b8%a7%e0%b8%97%e0%b8%b2%e0%b8%87%e0%b8%81%e0%b8%b2%e0%b8%a3%e0%b8%9b%e0%b9%89%e0%b8%ad%e0%b8%87%e0%b8%81%e0%b8%b1%e0%b8%99%e0%b8%81%e0%b8%b2%e0%b8%a3%e0%b8%95%e0%b8%b4%e0%b8%94","status":"publish","type":"post","link":"https:\/\/www.talingchanpet.net\/en\/%e0%b9%81%e0%b8%99%e0%b8%a7%e0%b8%97%e0%b8%b2%e0%b8%87%e0%b8%81%e0%b8%b2%e0%b8%a3%e0%b8%9b%e0%b9%89%e0%b8%ad%e0%b8%87%e0%b8%81%e0%b8%b1%e0%b8%99%e0%b8%81%e0%b8%b2%e0%b8%a3%e0%b8%95%e0%b8%b4%e0%b8%94\/","title":{"rendered":"Prevention of urinary tract infections"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"8037\" class=\"elementor elementor-8037\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-97113df elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"97113df\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5e4fb3a\" data-id=\"5e4fb3a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7c46f57 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"7c46f57\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><\/p>\n<p><\/p>\n<p class=\"wp-block-paragraph\">For the urinary tract to become infected&nbsp;<span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight );\">Bacteria must first enter the urinary tract by attaching to the urinary tract lining. They then multiply and persist in the urinary tract, causing inflammation. This inflammation is what causes the animal to exhibit various urinary tract symptoms.<\/span><\/p>\n<p>Therefore, if we are to prevent bacterial urinary tract infections, focusing on adhesion is the first thing to consider, called Anti-adhesive therapeutics. Anti-adhesive therapeutics uses a protein molecule called adhesin on bacterial fimbria (FimH), especially E. coli bacteria, which is found to be the most common cause of urinary tract infections, to bind to receptors on the urinary tract lining.&nbsp;<span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight );\">When they stick together, bacteria can multiply and cause inflammation.<\/span><\/p>\n<p>Therefore, anti-adhesive therapeutic works by binding certain substances to the bacterial FimH, preventing the bacteria from attaching to the urinary tract mucosa. Currently, two types of substances are being used to inhibit bacterial FimH, as follows:<\/p>\n<p>1. Cranberry extract&nbsp;<\/p>\n<p>It has been widely used in the prevention of recurrent urinary tract infections in humans. Cranberry contains natural bioactive tannins, such as proanthocyanidin, which have the ability to inhibit the adhesion of FimH to the urinary tract lining. Studies have shown that cranberry extract can inhibit the adhesion of E. coli to kidney cells. In veterinary medicine, there are studies that do not show a statistically significant protective effect. However, whether the studies were conducted in humans or animals, the consensus is that no side effects were found from the use of the extract. Therefore, the use of cranberry extract is considered another option for the prevention of recurrent urinary tract infections.<\/p>\n<p>2. D-mannose is a sugar that has antibacterial properties.&nbsp;<\/p>\n<p>The presence of D-mannose in urine can inhibit the adhesion of bacteria to urinary tract epithelial cells because D-mannose binds to FimH adhesin, which has a structure similar to the receptor on the urinary tract epithelium. D-mannose competes with FimH to bind, preventing bacteria from adhering to the urinary tract epithelium and being excreted in the urine.<\/p>\n<p><\/p>\n<p><\/p>\n<p class=\"wp-block-paragraph\"><\/p>\n<p><\/p>\n<p class=\"wp-block-paragraph\"><strong>Information from:<\/strong><\/p>\n<p>Dr.Sasipat Kittisarathamma (Dr.Mook)<br>Internal Medicine Center, Ultrasound Center<br>Veterinarian, Taling Chan Animal Hospital<\/p>\n<p><span style=\"font-weight: bolder; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif;\">References:<\/span><\/p>\n<p>Wachira Hunprasit. (2021). Prevention of urinary tract infections. From https:\/\/ readvpn.com\/Topic\/Info\/4812f658-9450-4371-87c7-8bbaac515f46.<\/p>\n<p><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>In order for the urinary tract to become infected, bacteria must first enter the urinary tract. The bacteria must adhere to the urinary tract lining. They will then multiply and remain in the urinary tract, causing inflammation. This inflammation is what causes animals to show various urinary tract symptoms. Therefore, if we want to prevent bacterial urinary tract infections, focusing on adhesion is the first thing to consider. This is called Anti-adhesive therapeutics. Anti-adhesive therapeutics uses a protein molecule called adhesin on bacterial fimbria (FimH), especially E. coli bacteria, which is the most common cause of urinary tract infections, to attach to receptors on the urinary tract lining. Once attached, the bacteria will multiply and cause inflammation. Therefore, anti-adhesive\u2026<\/p>","protected":false},"author":4,"featured_media":7994,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"rop_custom_images_group":[],"rop_custom_messages_group":[],"rop_publish_now":"initial","rop_publish_now_accounts":[],"rop_publish_now_history":[],"rop_publish_now_status":"pending","footnotes":""},"categories":[27],"tags":[611,463,516,690,591,593,436,433,672,615,603,605,424,495,124,251,165,599,423,191,613,322,609,588],"class_list":["post-8037","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-27","tag-611","tag-463","tag-516","tag-690","tag-591","tag-593","tag-436","tag-433","tag-672","tag-615","tag-603","tag-605","tag-424","tag-495","tag-124","tag-251","tag-165","tag-599","tag-423","tag-191","tag-613","tag-322","tag-609","tag-588"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - 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